Types and grades of non-Hodgkin lymphoma
Angioimmunoblastic T-cell lymphoma (AITL) is a rare type of non-Hodgkin lymphoma (NHL).
NHL is a type of blood cancer that affects white blood cells called . It is a cancer of the .
There are many different types of NHL. AITL is a type of peripheral T-cell lymphoma. It is fast growing (high grade).
Treatment is usually a combination of drugs. Doctors call this combination CHOP.
Symptoms can start or get worse in just a few weeks.
Painless swellings
The most common symptom is one or more painless swellings in the:
neck
armpit
groin
These swellings are enlarged . They can grow very quickly.
General symptoms (B symptoms)
You might have other general symptoms such as:
heavy sweating at night
high temperatures that come and go with no obvious cause
losing a lot of weight (more than one tenth of your total weight)
Doctors call this group of symptoms B symptoms. Some people may also have unexplained itching. It is important to tell your doctor about any symptoms like this.
Other symptoms
Lymphoma can grow in the bone marrow. Lymphoma cells can take up the space of normal blood cells. This can cause low blood cell counts. Symptoms of this includes:
tiredness and shortness of breath
bleeding and bruising
You might have a swollen or liver. This can cause bloating, and you might have tummy discomfort or pain.
The lymphoma cells produce abnormal proteins and the body reacts to these. Doctors call this as an autoimmune reaction. This can cause symptoms such as:
skin rashes
inflammation of your joints
Find out more about the symptoms of NHL
Grade
Grade describes how the cells look under a microscope. Your grade tells the doctor how quickly the lymphoma is likely to grow and spread. Doctors put NHL into 2 grades:
low grade (slow growing)
high grade (fast growing)
AITL is fast growing and doctors call it a high grade lymphoma.
Stage
You have tests to find out the number of places in your body affected by lymphoma, and where these are. This is your stage. Doctors use your stage to plan your treatment.
There are different systems for staging NHL. Your doctor can tell you more about your stage, and what it means.
There are 4 main stages of NHL (stage 1 to stage 4). Or your doctors might talk about early (limited) stage and advanced stage lymphoma. Early stage usually means either stage 1 or stage 2 lymphoma. Advanced stage usually means either stage 3 or stage 4 lymphoma.
Your treatment depends on:
where your lymphoma is (the stage)
your symptoms
your general health
The main treatments are:
a combination of drugs
a
as part of a clinical trial
Find out more about the treatments for NHL
You usually have a several chemotherapy drugs together. A common combination of chemotherapy drugs is called CHOP. This is a mixture of chemotherapy and steroids. It includes the drugs cyclophosphamide, doxorubicin, vincristine and prednisolone.
In some situations you might have a drug called rituximab alongside chemotherapy. Rituximab is a type of .
This combination is called chemoimmunotherapy and the regime is called R-CHOP.
A stem cell transplant allows you to have very high doses of chemotherapy. You can have a transplant using:
your own stem cells (autologous stem cell transplant)
a donor’s stem cells (allogeneic stem cell transplant)
You might have an autologous stem cell transplant as part of your first treatment for AITL. You might have it after your CHOP chemotherapy, if you responded well to the chemotherapy. This is to try and prevent your lymphoma from coming back. It is intensive treatment so you need to be well enough to have it.
Read more about stem cell transplants
You often have steroids together with chemotherapy for lymphoma. Sometimes you have steroids on their own to treat AITL.
Lymphoma that comes back after treatment is called relapsed disease. You might have:
further chemotherapy treatment using different chemotherapy drugs
a stem cell transplant using donor stem cells - an allogenic stem cell transplant
targeted cancer drugs on a clinical trial
Researchers around the world are looking at the treatments for NHL. Your doctor might suggest you take part in a clinical trial.
Read more about research into NHL
The best person to talk to you about your outlook or prognosis is your doctor. Not everyone wants to know. People cope differently with their lymphoma and want different information.
Survival depends on many factors. So no one can tell you exactly how long you will live. Your doctor might be able to give you some guide, based on their knowledge and experience.
Last reviewed: 19 Apr 2024
Next review due: 19 Apr 2027
Non-Hodgkin lymphoma (NHL) is a type of blood cancer that affects white blood cells called lymphocytes. It's the 6th most common type of cancer in adults.
There are many different types of non-Hodgkin lymphoma (NHL). Doctors also give NHL a grade, depending on how quickly it is likely to grow.
The stage tells you about the number and places in your body that are affected by lymphoma. There are 4 stages for NHL. Or doctors describe it as either early or advanced stage.
Your treatment depends on the type and stage of your NHL. Common treatments include chemotherapy, targeted and immunotherapy drugs, radiotherapy and a stem cell transplant.
Practical and emotional support is available to help you cope with non-Hodgkin lymphoma.
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