Oligodendroglioma

Oligodendrogliomas are a rare type of brain tumour that develops from glial cells called oligodendrocytes. They are more common in adults than in children.

Symptoms of oligodendroglioma depend on where the tumour is in the brain. Common symptoms include headaches and seizures (fits). 

Find out more about the symptoms of brain tumours

What does IDH mutant and 1p/19q co-deleted mean?

Your doctor looks to see if there are certain gene changes in the brain tumour cells. These tests are also called biomarkers or molecular studies. Your doctor uses these test results to decide what type of glioma you have. 

IDH (isocitrate dehydrogenase) is a gene. Your doctor looks for permanent changes (mutations) in the IDH gene.

1p and 19q refer to chromosome 1 and chromosome 19. 1p/19q co-deleted means that:

• part of the short arm (p) of chromosome 1 is missing (deleted)

• part of the long arm (q) of chromosome 19 is missing (deleted)

Your doctor diagnoses you with an oligodendroglioma if the glioma cells:

• have changes (mutations) in the IDH gene – this is what IDH mutant means

• are missing parts of chromosome 1 and chromosome 19 – this is what 1p/19q co-deleted means

Grades of oligodendrogliomas

Oligodendrogliomas are put into groups based on how quickly they are likely to grow. This is called the grade.

Generally, the more normal the cells look, the lower the grade. The more abnormal the cells look, the higher the grade. Grade also depends on genes and proteins in the tumour cells. 

There are 2 grades of oligodendrogliomas:

• grade 2 (low grade), sometimes called diffuse

• grade 3 (high grade), sometimes called anaplastic

Read more about the grades of brain tumours

How common it is

Oligodendrogliomas are rare. About 3 out of every 100 primary brain tumours (3%) diagnosed in England between 1995 and 2017 were oligodendrogliomas.

What tests will I have?

You have tests to diagnose an oligodendroglioma. Your doctor checks the size of the tumour and its location. This helps your doctor plan your treatment. The tests you might have include:

• ​MRI scan​ or ​CT scan​

• a ​biopsy​

• a test of your neurological system (neurological examination)

We have more information about the tests you might have to diagnose a brain tumour

Treatment

Treatment depends on whether the oligodendroglioma is low grade (slow growing) or high grade (fast growing).

The main treatments for oligodendroglioma are:

• surgery to remove as much tumour as possible

• radiotherapy, which uses high energy x-rays to destroy cancer cells

• chemotherapy, which uses cytotoxic drugs to destroy cancer cells

Treatment for low grade oligodendroglioma

Treatment for high grade oligodendroglioma

Treatment for oligodendroglioma that comes back

Your treatment depends on what treatment you have already had. You might have a combination of:

• chemotherapy with lomustine, temozolomide or PCV

• more surgery

• more radiotherapy

Coping with oligodendroglioma

Coping with a diagnosis of a brain tumour can be difficult, both practically and emotionally. It can be especially difficult when you have a high grade tumour. Being well informed about the type of tumour you have, and its treatment can make it easier to cope.  

Find out what you can do, who can help and how to cope with a brain tumour